| Firm | Location | Best For | Notable Clients | Price |
|---|---|---|---|---|
| #1 Code and Theory | New York, NY | Healthcare systems, hospitals, pharma, medtech | Major US healthcare systems | $$$$ |
| #2 Huge | New York, NY | Enterprise healthcare brands, large-scale digital platforms | Google · Delta · HBO | $$$$ |
| #3 Big Human | New York, NY | Healthcare apps, telemedicine, digital health startups | Digital health · telemedicine | $$$ |
| #4 AREA 17 | New York, NY (+ Paris) | Science-led healthcare brands, research institutions | Research institutions · biotech | $$$ |
| #5 Rightpoint | Chicago, IL | Enterprise healthcare CX, hospital systems, pharma | Hospital systems · pharma | $$$$ |
$$$ = premium · $$$$ = enterprise
Ranked by our editorial team based on portfolio quality, client outcomes, and industry reputation.
Best For
Healthcare systems, hospitals, pharma, medtech enterprise
Code and Theory is one of the most respected enterprise digital agencies in the US, and their healthcare practice is genuinely deep. They've worked with major healthcare systems, pharmaceutical companies, and medtech enterprises on everything from patient-facing portals to internal clinical platforms — work that requires equal parts strategic discipline, regulatory awareness, and design polish. Their NYC office leads many of these engagements, with the scale and process to handle multi-stakeholder healthcare clients where the brief involves clinicians, compliance teams, and the C-suite simultaneously. The right partner when "redesign our website" is actually "redesign our entire digital ecosystem."
Notable clients: Major US healthcare systems · pharma · medtech enterprise
Visit codeandtheory.comBest For
Enterprise healthcare brands, large-scale digital platforms, complex UX in regulated industries
Huge is one of the most influential digital experience agencies in the world, with a healthcare practice that includes major US payers, providers, and pharmaceutical companies. They work at the intersection of design, technology, and business strategy — helping healthcare brands build digital products that operate at scale across web, mobile, and connected devices. Their NYC headquarters handles complex healthcare engagements where the design challenge is matched by regulatory complexity (HIPAA, FDA, state-by-state compliance). If your healthcare organisation needs a true strategic partner — not just a design vendor — and has the budget to match that ambition, Huge sets the standard.
Notable clients: Google · Delta · Hershey's · HBO · enterprise healthcare
Visit hugeinc.comBest For
Healthcare apps, telemedicine platforms, digital health startups
Big Human is a New York-based product and brand studio with a strong track record in digital health — the kind of telemedicine apps, mental health platforms, and healthcare startups that need consumer-grade design polish on day one. They handle product, brand, and engineering in-house, which makes them particularly effective for healthcare startups where speed and end-to-end ownership matter as much as design quality. A natural fit when the client is a digital health Series A or B looking for a senior partner to take their product from early MVP to a polished, trusted experience.
Notable clients: Digital health · telemedicine · healthcare apps
Visit bighuman.comBest For
Science-led healthcare brands, research institutions, complex storytelling
AREA 17 is a New York-headquartered (with Paris office) digital agency known for handling intellectually serious clients — research institutions, scientific publishers, healthcare and biotech brands where the content itself is genuinely complex and needs design that respects the substance. Their work tends to be considered, typographically disciplined, and built for the kind of healthcare buyer who values intellectual credibility over flash. A natural fit for medtech, biotech, healthcare research, and clinical institutions that want their digital presence to feel as serious as the work they actually do.
Notable clients: Research institutions · biotech · healthcare publishing
Visit area17.comBest For
Enterprise healthcare CX, hospital systems, pharma digital transformation
Rightpoint is one of the largest enterprise customer experience agencies in the US, with a healthcare practice that runs across major hospital systems, pharmaceutical companies, and medical device manufacturers. Their Chicago HQ leads complex, long-engagement healthcare programs — the kind that involve service design, internal tooling, patient-facing platforms, and multi-year digital transformation roadmaps. The right pick for established healthcare organisations that need a partner with the scale, process, and regulatory experience to deliver across an entire digital ecosystem, not just a single website.
Notable clients: Major US hospital systems · pharma · medical devices
Visit rightpoint.comEvery industry has different requirements. We rank the best US web design agencies for each one — based on portfolio quality, client results, and industry reputation.
This project is run by a small team with deep experience in web design, digital strategy, and product development. We’ve worked at agencies, run in-house design teams, advised startups on their first website builds, and evaluated agency pitches from both sides of the table.
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Q1 and Q3 updates. Firms that slip are removed.